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Hwang HS, Maeng YS, Park YW, Koos BJ, Kwon YG, Kim YH

Excessive release of histamine can cause vasodilation, increased vascular permeability, and smooth muscle contraction in the cardiovascular system, which can disrupt normal cardiovascular function

Toxicology and Applied Pharmacology, 163 (2), 203207

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Treatment of exacerbations Early treatment of exacerbations is particularly important as it could probably limit the vicious circle of infection/inflammation that is a determinant factor of lung damage
