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Finally, the oxidative stress and protein nitration causes the opening of the mitochondrial membrane transition pore (MPTP) leading to the collapse of the membrane potential and cessation of ATP synthesis, which is the cause of cell death [37, 38]

In addition to its antioxidant properties that help replenish glutathione levels, NAC is also valued in nutrition and supplementation for its benefits in body homeostasis, improved immune function, and its contribution to protecting against cellular damage [1]

In addition, severe vitamin B 12 deficiency in patients with AIG may result in neurological damage, causing symptoms such as impaired peripheral nerve function and sensory, abnormal proprioception, ataxia, paresthesia, numbness, mood disorders, cognitive impairment and psychosis

Angeli et al., 2017)

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Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride