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Correlation with Gleason patterns 4 and 5 at prostate biopsy

For example, NRF2 transcriptional activation of glutamate-cysteine ligase catalytic subunit (GCLC) and glutamate-cysteine ligase modifier subunit (GCLM) increases the production of the ROS scavenger -glutamyl-cysteinyl glycine, more commonly referred to as glutathione (GSH) [6]

Among these, selenium-dependent glutathione peroxidase 4 (GPX4) is crucial for preventing ferroptosis by detoxifying phospholipid hydroperoxide into the corresponding phospholipid alcohol at the expense of glutathione (GSH) [12,13,14,15]

Glutathione may lighten skin by reducing melanin production, but the results are not usually permanent

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The concentrations of glutathione were then calculated from slopes of the absorbance changes in reference to the standard curve