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The promoters are tissue-specific, and AP-1, AP-2, and nuclear factor B (NFB) binding sites have been identified in the promoter region (Chikhi et al., 1999)

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In contrast, its paralog CHAC2 remains unresponsive, highlighting CHAC1s unique role in stress adaptation (Ward et al., 2024)

Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4

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Based on this evidence, the principle of senolytic approaches is to target Senecent Cell Anti-Apoptotic Pathways (SCAPs) by inhibiting or activating proteins which regulate this apoptosis resistance 8,9