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Glutathione actively functions as an antioxidant ONLY in its reduced form (GSH or L-Glutathione) and not in its oxidised form (GSSG)

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Mechanistically, it influences gene networks involved in tissue remodeling and exerts protective antioxidant and anti-inflammatory actions, partly through TGF- signaling and regulation of metalloproteinases

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Pathophysiological changes in astroglia can be primary or secondary and can result in gain or loss of functions

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* Exposing transfected cells to oxidizing ($H_2O_2$) and reducing (DTT) conditions to assess redox responsiveness

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