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They usually take it at night before bed

This is because the mutant RAS signal may increase the concentration of intracellular free iron by regulating the expression of iron metabolism-related genes (such as FTH1 and TFRC), which in turn increase the sensitivity of cells to ferroptosis [27, 93]

To address these barriers, advanced drug delivery systems (e.g., nanoformulations, liposomal carriers, prodrugs) are being explored to enhance bioavailability and targeted drug delivery to the brain

28 Importantly, the risk persisted despite the improvement regarding traditional cardiovascular risk factors such as hypertension, dyslipidemia or diabetes

Conversely, while broad-spectrum PHD inhibitors (e.g., Roxadustat [489]) promote erythropoiesis to treat anemia, their potential pro-oxidant side effects also require careful evaluation, reflecting the dual nature of intervention strategies

Based on this responsive strategy, researchers developed self-assembled nanoparticles that were glutathione-responsive drug release polymer micelles [185,186,187]