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A meta-analysis of 12 studies (that included ten cohort and two case-control studies) found no overall change in PDAC risk amongst GLP-1RA users

Well-hydrated kidneys can effectively dilute waste products, whereas dehydration forces them to conserve water, leading to more concentrated urine

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However, older patients, commonly those older than 65 years, often present with vague or atypical symptoms in conditions associated with vitamin B12 deficiency [6]

Paresthesias and gait disturbances may begin to improve within two weeks, although full recovery can take several months

Early markers like improved glucose disposal and reduced postprandial fatigue precede visible body composition changes by several weeks