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however, theoretical risks include off-target activation of the HGF/c-Met pathway, which is implicated in oncogenesis, warranting caution regarding long-term use

A.YassinM

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When to increase dose Consider increasing if: Minimal response after 4-6 weeks at current dose No side effects at current dose Current dose below the higher end of recommended range Goals not being met with conservative approach Increase gradually, typically by 25-50% at a time

Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway