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Adsorptive-mediated transport at the BBB has also been exploited to target nanocarrier systems by using cationic lipids and cell penetrating peptides to increase binding and internalization at the brain capillary endothelium [29, 30], which has a highly negative surface charge [31]

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48 Richardson et al

The key is bioavailability

As understanding of the HGF pathway deepens, Dihexa will likely serve as the reference standard for growth-factor-mediated cognitive enhancement studies

This is one of the first peptide-based therapies for disc disease to reach human clinical trials, and its outcomes will significantly influence the field