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The absence of data is the default outcome of how testing works, not a red flag specific to this ingredient

The Bigger Concern: Leaving a Deficiency Untreated When weighing the minimal risks of B12 injections, it helps to consider the well-documented risks of an untreated B12 deficiency

Additionally, B12 deficiency elevates homocysteine a marker of vascular endothelial damage

[DOI] [PubMed] [Google Scholar] 42.Giusti B., Saracini C., Bolli P., et al

While this sounds painful, it actually is relatively painless for most people