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411 Therapeutic strategies involving the blockade of IL-1 signaling to inhibit Nlrp3-dependent B cell accumulation or the targeted depletion of B cells within adipose tissue via anti-CD20 antibodies have been shown to mitigate metabolic dysfunction in aged AT

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Material and methods We performed a comprehensive literature search for relevant articles using PubMed and the following MeSH terms: Sjgrens syndrome, biologic therapies, T cell targeted therapy, B cell targeted therapy, abatacept, baminercept, belimumab, rituximab and epratuzumab

doi: 10.1111/j.1440-1797.2007.00833.x