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IGF family includes three known ligands (IGF-I, IGF-2 and insulin), six characteristic insulin-like growth factor binding proteins (IGFBP-1-6) and cell surface receptors (IGF-1 receptor, insulin receptor and IGF-II mannose 6-phosphate receptor) that mediate ligand action[36-38]

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In fact, strategies aimed at buffering microenvironment pH before administration of standard chemotherapy have been proposed by both preclinical 42 and clinical studies [Clinical trials NCT01198821] 43

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A heat map of the highest fold change and statistically significant differential gene expression between CAQK treated vs vehicle-treated mouse brains is shown in Fig