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10.1016/j.cell.2015.04.042 Summary Keywords intervertebral disc, low back pain, MSC, regenerative medicine, microenvironment, niche, extracellular vesicles (EVs), disc progenitor cells Citation Wang H, Xu A, Hua W, Mao J, Zhang J, Ma X and Lu L (2025) Stem cell-based strategies for intervertebral disc regeneration in degenerative microenvironments: challenges and solutions

Initial results demonstrated that several N- and C-terminal modifications lead to dramatically improved stability while maintaining the capability to reverse scopolamine-induced deficits in Morris water maze performance and augment hippocampal synaptogenesis

The last one that I think we want to dive into today, just for the sake of time, Id love to hear you talk a little bit about the importance of social connections because you just said you have to be willing to get uncomfortable

In silico analysis evidenced that SSTR2 was a putative target of miR-185 and, intriguingly, miR-185 was upregulated in tumor samples from SSA non-responder adenoma patients with respect to controls while it was downregulated in the SSA responder patients (48)