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The anti-inflammatory effects of melatonin occur by inhibiting the transcription factors involved in generating pro-inflammatory cytokines (e.g., activator protein 1, hypoxia-inducible factor-1, nuclear factor erythroid 2 factor 2, and nuclear factor kappa B), prostaglandin synthesis, reduced the production of adhesion molecules, neutrophil infiltration into tissues, and COX-2 (cyclooxygenase-2) levels