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Lyophilized peptides retain stability at room temperature for brief periods (typically fewer than 7 days without desiccant protection), though -20C storage is strongly recommended for extended stability exceeding one month

However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

primary endpoint not met

Circadian Timing: DSIP effects may vary with circadian phase

Edited by Anna Paschall Hannum

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