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Tendon and Ligament Support : Preclinical studies investigate mechanisms that may influence structural repair in connective tissues under stress or injury

Nohria, A., Desai, D., Paez-Garcia, M

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These changes place the system in a state of constant regulation, which leads to changes in the expression, localization, function, downstream signaling, and constitutive activity of GPCRs, G proteins, and arrestins

Experimental models reveal DSG-mediated suppression of lipogenic regulators (sterol regulatory element-binding protein 1c (SREBP- 1c) and fatty acid synthase (FAS)) with concurrent upregulation of lipolytic enzymes (phospho-AMPK (p-AMPK), phospho-acetyl-coA carboxylase (p-ACC), and carnitine acyl transferase 1 A (CPT- 1 A)), effectively reducing ectopic lipid deposition [460]

Polypeptide ligands include the metallothioneins (MTs), small, gene-encoded, cysteine-rich polypeptides, and the phytochelatins (PCs), which, in contrast, are enzymatically synthesized are effective metal binding ligands have been identified