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Description
The ECI1 and ECI2 encoded enzymes catalyze the transformation of 3-cis and 3-trans-enoyl-CoA esters that are the result of the mitochondrial -oxidation of cis-, mono-, and polyunsaturated fatty acids

That clue came about from research on a drug called bremelanotide, which was originally developed and tested as a sunless tanning agent

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Radial growth phasemelanomas do not tend to invade the underlying reticular dermis, but they are associated with metastasis