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Masson staining analysis indicated that control mice had significant hepatic fibrosis compared to mice with GSTM2 overexpression (Supplementary Fig

Mitochondria acting as a sink for GSH may thus play an important role in signaling and H 2 O 2 -detoxification [165,166] and therefore be an important survival strategy to prevent cytochrome c -induced cell death [171,172]

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However, larger trials have not consistently shown mortality benefit (Rank et al., Crit Care Med, 2000) [41]

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