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119 During lysosomal damage, another mammalian autophagy-related protein, MAP1LC3B, is rapidly and directly conjugated onto lysosome membranes

AC5KO mice are found to be resistant to cardiac stress with an enhanced median life span of roughly 30%, with protection from bone demineralization, and decreased susceptibility to fractures or aging-induced cardiomyopathy (Yan et al., 2007)

Antioxid Redox Signaling

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ATX inhibitors Multiple in vitro and in vivo studies, including genetic knockout models, have demonstrated that ATX inhibition can mitigate disease progression across a wide spectrum of pathological conditions

Osteoarthritis Mahdavi et al