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While expression of FMO5 in the small intestines is independent of the bacteria present, there is evidence to suggest that a high fat diet does influence FMO5 expression in the small intestines, but this was tissue specific as an increase in FMO5 liver expression was not observed ( Conclusion Even though compounds such as DMB and dietary indoles have shown promise as a therapeutic intervention for CVD and T2D there is still much that can be improved upon in their chemical structures