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In conclusion, histone Kla is closely related to M2 polarization of TAMs, and increased levels of Kla tend to cause immunosuppression and reduce the efficacy of immunotherapy

doi: 10.1016/j.freeradbiomed.2022.04.011 101 FutagamiSHiratsukaTShindoTHorieAHamamotoTSuzukiKet al

Its application has also been extended to chronic wound and ulcer management

Accepted: 10/12/2021

It plays a critical role in tissue remodeling, wound healing, collagen production, and anti-aging processes

Feo S Expression of Alpha-Enolase (Eno1), Myc Promoter-Binding Protein-1 (Mbp-1) and Matrix Metalloproteinases (Mmp-2 and Mmp-9) Reflect the Nature and Aggressiveness of Breast Tumors