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Yao R., Zhang Y., Yu W., et al., Jianpihuayu Decotion Regulates TREM1/DAP12 Pathway to Improve the Immunosuppressive Tumor Microenvironment and Enhance the Antihepatocellular Carcinoma Effect of PD1 Inhibitors, Journal Of Ethnopharmacology 356 (2026): 120846

Harper C, Hayward D, Wiid I, van Helden P: Regulation of nitrogen metabolism in Mycobacterium tuberculosis: a comparison with mechanisms in Corynebacterium glutamicum and Streptomyces coelicolor

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It achieves this by modulating the Nrf2/HO-1 signaling pathway and facilitating the release of antioxidant and anti-inflammatory proteins

This "first-pass effect" further reduces the amount of active drug that reaches its target receptors