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Upon antigen encounter, successful activation triggers a metabolic shift: Effector T cells upregulate aerobic glycolysis (the Warburg effect) to rapidly generate biosynthetic precursors (nucleotides, amino acids, lipids) necessary for clonal expansion and cytokine production, while still maintaining OXPHOS capacity

The tablets should be swallowed with water, preferably after meals to minimize gastrointestinal discomfort

J., Lan, M

DKD is therefore characterized by excessive production of ROS and destruction of antioxidant defense mechanisms [54]

J., Alhomida, A

Careful titration of JUXTAPID may then be considered based on LDL-C response and safety/tolerability to half the maximum recommended dosage except when co-administered with oral contraceptives only, in which case the maximum recommended JUXTAPID dosage is approximately two thirds of the maximum recommended dosage (Table 3) [see Dosage and Administration (2.4), Warnings and Precautions (5.6), and Clinical Pharmacology (12.3)]