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Although VEGFA is located in another chromosome, its overexpression in mice embryos triggers severe heart development abnormalities (Miquerol et al., 2000)

Each addition should answer a specific question

Physiological reviews

[Google Scholar] 53.Franca L, Suescun M, Miranda J, Giovambattista A, Perell M, Spinedi E, et al
Following the identification of oxidative stress-related genes (HMOX1, DNAJB1, GADD45B), higher expression levels were observed in HepG2 ATP7B-KO cells compared to HepG2 cells

MTHFR stands for methylenetetrahydrofolate reductase, the enzyme that helps convert folate into its active, methylated form (5-methyltetrahydrofolate)