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[DOI] [PMC free article] [PubMed] [Google Scholar] [35].Petris MJ, Smith K, Lee J, et al

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Similarly to CQ, treatment with leupeptin/NH 4 Cl resulted in the downregulation of both VEGFR3 and PROX1 proteins (Supplementary Fig

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However, for rats treated with high doses of curcumin, IL-1 and oxidised protein levels were reduced whereas no significant difference in A deposition was observed thus indicating that the mechanism of action of curcumin had different dose requirements that could counterbalance each other at higher dosages [296]