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Erythrocyte NAD(H) levels started to saturate already with 500-750 mg of niacin and increasing the dose up to 1000 mg had only a slight additional effect on steady-state NAD + in blood cells

doi: 10.1073/pnas.1000087107

But what if that trade-off is no longer necessary

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The good Samaritan glutathione-S-transferase P1: an evolving relationship in nitric oxide metabolism mediated by the direct interactions between multiple effector molecules

The weight loss continues at the current dose while your system adapts