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Acetaminophen Lipid peroxidation The hypothesis that LPO is the main cause of APAP hepatotoxicity was introduced by Wendel and coworkers 35 years ago, 38,5658 contrasting the previously established idea that protein binding of a reactive metabolite generated by cytochrome P450 is the key event in cell death
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1991;42 (Suppl):S47S54
& Ho, J
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Ethacrynic acid is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation
