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Journal of Clinical Oncology

With declining estrogen, you become more prone to losing lean mass and storing fat, especially around the midsection

Pharmacol Biochem Behav 50 : 147151 Gambarana C, Masi F, Tagliamonte A, Scheggi S, Ghiglieri O, De Montis MG

Carvalho, B
On the other hand, a primary defect in energy metabolism (mitochondrial disease, genetic component being in a gene involved in energy metabolism) will result in delayed homeostasis of the ion gradient in active neurons and their associated glia due to under function of the ATP-dependent cation pumps
