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Understanding Potential Side Effects

Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

doi: 10.1016/j.biocel.2017.10.004

At a pace of five to ten percent each year, the quantity of LA that is being used is growing because of the expansion of the economy

& Ney, P

Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects