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An uncontrolled trial that included 24 depression patients who had not responded to four weeks of SSRI treatment found the addition of 160 mg aspirin per day resulted in a 52.4% response rate and a 43% remission rate

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[ 78 , 79 , 80 ] Nevertheless, additional investigation is required to comprehend the mechanisms through which BACH1 expression is induced, including low oxygen induction, oxidative stressinduced inflammatory factors, hormones and cytokines, and other potential pathways

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