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Tirzepatide and sermorelin together represent a combination therapy approach that some patients and clinicians consider for metabolic management, though this pairing lacks formal clinical study

This leads to reduced hunger, increased feelings of fullness, and delayed gastric emptying, collectively resulting in decreased caloric intake

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doi: 10.1097/00000441-199907000-00006, PMID: [DOI] [PubMed] [Google Scholar] 59

They can also worsen blood sugar control in people with type 2 diabetes

At the same time, glycine is also an obligatory co-agonist at N-methyl-D-aspartate (NMDA) receptors, a type of excitatory glutamate receptor in the brain