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In female strain A mice (a strain with a high spontaneous incidence of lung tumors), intraperitoneal injection of NNK caused benign and malignant lung tumors (adenoma and carcinoma)

J Biol Chem 281: 1042010430 Lee DW, Kaur D, Chinta SJ, Rajagopalan S, Andersen JK (2009) A disruption in ironsulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathionedepleted dopaminergic cells: implications for Parkinsons disease

But then you see the Britney Spears of the world and these other people and you go, oh man, I don't think that was really good for them, you know

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Neurotoxic effect of Hg is known for years

[DOI] [PubMed] [Google Scholar] Nencioni L, Iuvara A, Aquilano K, Ciriolo MR, Cozzolino F, Rotilio G, Garaci E, Palamara AT