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LRRK2 gene, which is associated with both familial and idiopathic forms of the disease, encodes leucine-rich repeat kinase 2 (LRRK2), a kinase that regulates secretory and endocytic vesicle trafficking by phosphorylating a group of Rab peripheral membrane proteins ( GBA , the gene encoding the enzyme glucocerebrosidase, which plays an important role in the autophagy-lysosome pathway, significantly increase the risk of Parkinsons disease (Mazzulli et al., 2011

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