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63 Role of inflammasome activation in APAP-induced liver injury Inflammasome activation has been implicated in the pathogenesis of various hepatic and systemic inflammatory diseases, including nonalcoholic fatty liver disease, 6769 alcoholic liver disease, 70,71 viral hepatitis, 72 and sepsis-induced liver injury

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Tn mutants in ruvA and ruvB both were attenuated in wild-type mice and had reduced vls recombination when isolates were analyzed after recovery from infected mice

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Yamaguchi, A

This makes it less likely to cause systemic side effects like water retention, insulin resistance, or abnormal growth of tissues