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While in animals the disease is modeled by a single instillation or repetitive exposure to the pathogen for several days/weeks, a mode of the lung injury in humans is mostly different as it includes chronic inflammatory, oxidative, and fibrotic changes in the tissue due to cumulative targeting of the lung

doi: 10.1007/s40279-015-0323-x

As expected, many of these genes were metabolism-related, including glutathione metabolic process, pentose-phosphate shunt and glucose 6-phosphate metabolic process (Fig

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J Exp Med 213, 11331139 (2016)

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