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Propylthiouracil (PTU) and methimazole are the two thionamide antithyroid drugs available for use in the United States

10.1196/annals.1320.005

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Benkherouf AY, Eerola K, Soini SL, Uusi-Oukari M

Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy

Any dysfunction in this chain of events caused by lack of cofactors or mitochondrial dysfunction would lead to reduced ATP formation and increased ROS, Ca 2+ and long chain fatty acid acyls and acylcarnitine buildup