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Thus, the lack of in vivo experiments significantly impedes progress

An RCT in 36 patients with type 2 diabetes found that NAC (1,200 mg/day for 4 weeks) combined with a standard diabetes diet significantly reduced fasting glucose, HbA1c, and markers of oxidative stress compared to diet alone (Shahidi et al., J Diabetes Metab Disord, 2020) [56]

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It can degrade several components of the ECM, including fibrillar collagen 1, and is particularly important for processes like human monocyte endothelial transmigration and chemokine and nitric oxide-induced angiogenesis