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While exerting its pharmacological effects, precise dosage control is essential, requiring further in-depth investigation by researchers

While Pt(II)-intrinsic resistance is common in colorectal and non-small lung cancers, acquired resistance is described in gynecological cancers [6], testicular, head and neck [4] and breast cancer (BC) [7]

2012;16(4):R134

Our finding that LDHB silencing activates STAT1, a key effector of the INF-/JAK pathway, which suppresses the expression of SLC7A11 is plausibly consistent with the notion that LDH has additional roles beyond glycolysis [23], although the possibility that lactate rather than LDHB itself modulates INF-/JAK pathway activity cannot be completely excluded [67]

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