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*Correspondence: Ritsuko Shimizu, [email protected] Specialty section: This article was submitted to Hematology Oncology, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Determination of the level of eicosanoids Eicosanoids level was performed using the modified method of Watkins and colleagues 20

Jiang Y, Wong JH, Fu M, Ng TB, Liu ZK, Wang CR, Li N, Qiao WT, Wen TY, Liu F

Penicillamine products ( R )-5,5-Dimethylthiazolidine-4-carboxylic acid 5 : The title compound was observed when penicillamine (4.34 mM) was allowed to react with HCHO (10 equiv.) for 30 min

The analyses were repeated for selected drug groups where drug use was defined as yes/no during the 6-month period before each SveDem entry date and in subgroups defined by gender and age