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In the twentieth century, however, scandals involving unregulated medical products helped swing the balance of power toward regulation

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Methylmalonic acid is an organic acid

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Glutamate, while crucial for these processes, can lead to neuronal damage and death when present in excessive amounts

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Loss of TSC1 or TSC2, the negative regulators of mTORC1, results in constitutive activation of mTORC1, which leads to the accumulation of p53 protein and increased apoptosis in response to stress conditions (e.g

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Malabsorption : Some people may have difficulty absorbing vitamin B12 from the diet due to certain medical conditions or the use of certain medications, such as proton pump inhibitors (PPIs) or H2 blockers, which reduce stomach acid production

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Figure 2 illustrates the known or predicted functional location of the protein products of these genes

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