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So why is there a discrepancy between these findings and those of meta-analyses of published Mendelian randomization studies

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What are the causes of B12 deficiency

The absence of effects on blood glucose, insulin sensitivity, blood pressure, and heart rate makes it safer than many alternatives for metabolic research

Cells characterized by rapid division (epithelial cells, bone marrow, myeloid cells) appear to have the greatest requirement for methylcobalamin

Lee WY, Park JS, Noh SY, Rhee EJ, Kim SW, Zimmet PZ