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In a targeted DNA methylation study focusing on five genes involved in fibrogenesis modulation, the results showed hypomethylation of pro-fibrogenic genes (TGF1 and PDGF) and hypermethylation of anti-fibrogenic genes (PPAR and PPAR) in advanced MASLD compared to mild cases, suggesting that the methylation status of specific CpGs could potentially predict the severity and progression of MASLD to liver fibrosis [340]

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It has more damage to address, and healing takes longer

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Hence, the use of combination therapies to target multiple metabolic pathways to suppress tumor growth may be most effective, especially in identifying cases that induce synthetic lethality, where two drugs induce cell death in combination, but not individually

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