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The soluble protofibrils formed from -synuclein exert their cytotoxicity through disruption of mitochondrial function, promotion of autophagy, lysosomal impairment and loss in regulation of calcium homeostasis (Van Laar et al., 2020), the two primary reasons accounting for loss in cellular homeostasis

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Researchers have also linked altered barrier function to disorders including irritable bowel syndrome and food allergies, and the association between high permeability and inflammatory conditions is an active, legitimate area of study

Apart from its immune suppressive effects in CD8 + T cells [197], methylglyoxal also promotes TAMs polarization and breast, colon, and liver tumor cells growth [198]