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Research has shown that during external pathogen infection, the xCTGPX4 antioxidant system helps to suppress the occurrence of ferroptosis in effector CD8+ and CD4+ T cells, promoting their expansion and enabling them to mount an immune response against pathogen invasion (4)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 345.Foong R.E., Bosco A., Jones A.C., Gout A., Gorman S., Hart P.H., Zosky G.R
[DOI] [PubMed] [Google Scholar] 5.Corona G., Cucinotta D., Di Lorenzo G., Ferlin A., Giagulli V.A., Gnessi L., Isidori A.M., Maiorino M.I., Miserendino P., Murrone A., et al
It plays a critical role in development, maintenance of tissue homeostasis, immune regulation, and the elimination of abnormal cells in the body [84]
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