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Handfoot skin reaction caused by multi-kinase inhibitors TKIs have been associated with various cutaneous AEs, including nonspecific morbilliform rash, mucositis, alopecia, changes in skin color, splinter hemorrhages, edema, ulcers and delayed healing, palmar-plantar rash, and scrotal or vulvar erythema-eczema

Oral administration of liposome-embedded SOD (L-SOD) could ameliorate oxidative damage and inflammatory responses via inhibition of myeloperoxidase (MPO) and pro-inflammatory cytokines, as well as protect gut barrier function by promoting the expression of the tight junction proteins occludin and zonula occluden (ZO)-1 in the colon 750

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