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10.1017/S0007114508942148

Km_mouse = 3, Km_rat = 6, Km_human = 37): CUR 80 mg/kg (mouse) HED 80 (3/37) = 6.5 mg/kg (~455 mg/day for 70 kg adult)

In our model oxidative stress is represented by an elevated level of H 2 O 2 which induces many changes in one-carbon metabolism and the transsulfuration pathway

NRF2 addiction provides an exciting therapeutic opportunity especially in the context of multimodality therapy and several promising small molecule inhibitors are currently in clinical trials

Its antioxidant property also protects the skin from UV radiation and other environmental as well as internal stressors that generate free radicals that cause skin damage and hyperpigmentation

This is clinically important because a physiological pulse pattern does not produce the receptor desensitization or side effect profile associated with direct GH injection