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Stytontriterpene D (STD), for instance, significantly reduced inflammatory cell recruitment in tail fin amputation and CuSO 4 -induced models by inhibiting the expression of NF-B p65 and IB (Yu et al., 2025)

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Pharmacologic inhibition of SIRT2 enhanced antitumor immunity by promoting metabolic reprogramming toward a profound hyper-metabolic state with enhanced capacity for aerobic glycolysis in tumor-infiltrating T cells [133]

Subsequently, the Amplex Red reaction mixture containing 100 M Amplex Red reagent and 0.2 U/mL horseradish peroxidase in KRPG buffer was added at 50 L to each well, and the fluorescent intensity was determined using SpectraMax ID5 microplate reader with excitation at 535 nm and emission at 590 nm at the indicated time points