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Theories include the induction of an intravascular lipid sink, or alternative lipid binding surface for the xenobiotic, effectively inactivating a percentage of the drug

Figure 1C shows the distribution of PIEZO1 expression in control and DIC groups

Baity M, Wang L, Correa AM, Zhang X, Zhang R, Pataer A, Wu S, Meng QH, Antonoff MB , Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Zhao M, Gu J, Fang B

No ethical approval is required

They dont have major side effects

Abstract Reactive oxygen species can oxidatively modify enzymes to reroute metabolism according to tumor needs, rendering identification of oxidized proteins important for understanding neoplastic survival mechanisms