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Trimethyl-lysine residues are the primary precursors for carnitine biosynthesis, which are hydroxylated on the third carbon by the enzyme trimethyl-lysine deoxygenase (TMLD) in mitochondria of liver, kidney, heart, muscle and brain [5]

This disorder of acylcarnitine metabolism promotes a continuous inflammatory response and thus plays a key role in the pathological process of N-ERD [45]

Ann Rev Immun

(PubMed) Schulzke SM, Patole SK, Simmer K

[DOI] [PubMed] [Google Scholar] 23.Kreider RB, Melton C, Rasmussen CJ, Greenwood M, Lancaster S, Cantler EC, et al

A mixture of 13 pesticides, contaminants, and food additives below individual NOAELs produces histopathological and organ weight changes in rats