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After four weeks of application of the KD, decreases in body weight (of 11.5 kg) and BMI (to class II obesity from class III) were observed, as well as stabilization of mood, reduction in anxiety and normalization of daily rhythm

F., Dale, C

Hoops D, Flores C

These changes occur in active sites, leading to a decrease in encoded protein activity, decreased excretion of foreign substances, and suboptimal catalytic efficiency

In this field, a crucial inflammatory factor, IL-1, was observed downregulated by Lactobacillus gasseri NK109 with the simultaneous upregulated expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of mice with cognitive impairment and depression induced by Escherichia coli K1, suggesting its alleviation in brain inflammation against neuropsychiatric disorders caused by bacterial infection [86]